Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8.3
USERS' SCORE
Good
Based on 19 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Prenatal Probiotic BlendLactobacillus rhamnosusLactobacillus rhamnosus HN001Lactobacillus acidophilusLactobacillus plantarumLactobacillus paracaseiLactobacillus brevisLactobacillus bulgaricusLactobacillus caseiLactobacillus gasseriLactobacillus reuteriLactobacillus salivariusTotal Lacto Cultures (15 Billion CFU)Bifidobacterium longumBifidobacterium infantisBifidobacterium bifidumBifidobacterium breveBifidobacterium lactisTotal Bifido Cultures (5 Billion CFU)
170 mg
+
Total Probiotic Cultures
20 Billion CFU¹
Organic Prebiotic Fiber BlendOrganic Potato (Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
115 mg
+
Top Medical Research Studies
9
We examined the effect of lactic acid bacteria, particularly Lactobacillus gasseri, on the harmful yeast Candida albicans. Our study showed that the metabolites from L. gasseri effectively inhibit the yeast's ability to grow and form biofilms, crucial for its pathogenicity. The research also indicated that these beneficial bacteria can keep C. albicans in a less harmful state by downregulating important genes responsible for its virulence. Overall, L. gasseri appears to be a promising option in the fight against vaginal yeast infections.
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9.5
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
Most Useful Reviews
9
Effective for infections
7 people found this helpful
I’ve been taking these probiotics throughout my pregnancy and so far, all is well! They’re vegan-friendly, and I store them in the fridge. If you get yeast infections during pregnancy, you can use them intravaginally, which worked like a charm for me without any chemicals.
Read More
9
Prevents infections
The high-quality ingredients in this product are excellent, especially for the prenatal stage, as they help prevent yeast infections in the birth area. It's important to maintain beneficial bacteria in the body, particularly if needing antibiotics before birth.
Read More
9
Prevented yeast infections
8 people found this helpful
Initially, I purchased these probiotics at GNC, and some capsules were broken. Despite this, I have been taking them daily after strong antibiotics during pregnancy and have had zero issues. Previously, antibiotics led to yeast infections, so I’m grateful to have discovered these!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8.3
- All Researches
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9.5
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
Read More
9
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for infections
7 people found this helpful
I’ve been taking these probiotics throughout my pregnancy and so far, all is well! They’re vegan-friendly, and I store them in the fridge. If you get yeast infections during pregnancy, you can use them intravaginally, which worked like a charm for me without any chemicals.
Read More
9
Prevents infections
The high-quality ingredients in this product are excellent, especially for the prenatal stage, as they help prevent yeast infections in the birth area. It's important to maintain beneficial bacteria in the body, particularly if needing antibiotics before birth.
Read More
9
Prevented yeast infections
8 people found this helpful
Initially, I purchased these probiotics at GNC, and some capsules were broken. Despite this, I have been taking them daily after strong antibiotics during pregnancy and have had zero issues. Previously, antibiotics led to yeast infections, so I’m grateful to have discovered these!
Read More
7.5
Gut health improved
7 people found this helpful
This product really helped improve my gut health. I highly recommend it for pregnant women who often experience BV or yeast infections. I haven’t had BV since using this after antibiotics a few months ago!
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9
Prevented yeast infections
4 people found this helpful
I believe this helped prevent yeast infections during my pregnancy.
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Frequently Asked Questions
7.5
Less infections
1 people found this helpful
After using it for a day, I noticed a significant reduction in my gynecological infections. I'm not pregnant, but I wanted to be cautious in case I do become pregnant.
6
Relieves infections
After a month of trial: Very effective for stomach issues like heartburn, reflux, indigestion, and bloating. It helps relieve constipation, but it doesn't provide a permanent solution. Its best feature is combating yeast infections effectively.
7.5
No more yeast infections
2 people found this helpful
Recommended by my OBGYN for persistent UTI's and yeast infections during pregnancy, these probiotics have resolved those issues completely since I began taking them after breakfast. Always consult your OB before taking any supplements!
7.5
Averted yeast infections
5 people found this helpful
The capsules are small and easy to take, helping with pregnancy nausea and constipation without causing an upset stomach. They improve digestion during and after pregnancy and balance gut pH, leading to better digestion. They also help in averting yeast infections, which are common during pregnancy.
9
Prevents infections
The high-quality ingredients in this product are excellent, especially for the prenatal stage, as they help prevent yeast infections in the birth area. It's important to maintain beneficial bacteria in the body, particularly if needing antibiotics before birth.
9
Cured vaginal infections
2 people found this helpful
These excellent capsules helped me eliminate vaginal infections during pregnancy while boosting my immunity.
8
Reduces infections
I found some benefit from this during my pregnancy as it reduced infections, thankfully, while I adhered to the instructions provided.
7
We examined a series of studies focusing on the effects of Lactobacillus probiotics against Candida species, which cause yeast infections affecting many adult women. Reviewing 15 articles from 2015 to 2020, we noticed that particular strains like L. acidophilus can inhibit Candida growth.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
8
Lactobacillus aids yeast infection treatment
We examined the antifungal properties of lactic acid bacteria, specifically Lactobacillus acidophilus and others, isolated from healthy women's vaginas. Through a method called agar diffusion, we identified how effective these bacteria were against Candida species, known to cause yeast infections.
Our findings showed promising antifungal activity among several Lactobacillus strains, including L. acidophilus, against various Candida strains. This indicates that these lactic acid bacteria could be valuable as probiotics in preventing and managing vaginal candidiasis. Further research in this area will continue to explore these benefits.
Our findings showed promising antifungal activity among several Lactobacillus strains, including L. acidophilus, against various Candida strains. This indicates that these lactic acid bacteria could be valuable as probiotics in preventing and managing vaginal candidiasis. Further research in this area will continue to explore these benefits.
8
We examined the impacts of combining standard azole therapy with a local probiotic treatment to combat recurrent yeast infections. Involving 436 women, we divided participants into two groups: one receiving standard azole treatment alone and the other receiving the same treatment along with Lactobacillus acidophilus probiotics.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
8
Probiotics inhibit Candida biofilm growth
We investigated how probiotics, particularly Lactobacillus acidophilus and its relatives, affect the development of Candida albicans biofilms. Our findings revealed that these probiotics notably decreased biofilm growth and altered the yeast's growth behavior.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
References
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- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. doi:10.1128/spectrum.02696-21
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- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. doi:10.1007/s10096-015-2447-1
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- Ishikawa KH, Mayer MP, Miyazima TY, Matsubara VH, Silva EG, et al. A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015;24:194. doi:10.1111/jopr.12198
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. doi:10.1007/s00284-024-03800-y
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- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. doi:10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. doi:10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. doi:10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. doi:10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. doi:10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. doi:10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. doi:10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. doi:10.1016/j.micpath.2017.08.006
- Boahen A, Chew SY, Neela VK, Than LTL. Limosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis. Probiotics Antimicrob Proteins. 2023;15:1681. doi:10.1007/s12602-023-10050-0
- Kraft-Bodi E, Jørgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015;94:181S. doi:10.1177/0022034515595950
- Chew SY, Cheah YK, Seow HF, Sandai D, Than LT. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118:1180. doi:10.1111/jam.12772
- Oncel MY, Arayici S, Sari FN, Simsek GK, Yurttutan S, et al. Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants. J Matern Fetal Neonatal Med. 2015;28:1790. doi:10.3109/14767058.2014.968842
- Wagner RD, Johnson SJ. Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans. J Biomed Sci. 2012;19:58. doi:10.1186/1423-0127-19-58
- Martinez RC, Seney SL, Summers KL, Nomizo A, De Martinis EC, et al. Effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the ability of Candida albicans to infect cells and induce inflammation. Microbiol Immunol. 2009;53:487. doi:10.1111/j.1348-0421.2009.00154.x
- Martinez RC, Franceschini SA, Patta MC, Quintana SM, Candido RC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl Microbiol. 2009;48:269. doi:10.1111/j.1472-765X.2008.02477.x
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- Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K. Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats. Histol Histopathol. 2016;31:689. doi:10.14670/HH-11-710
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- Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, et al. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93:884.
- Kang CH, Han SH, Kim Y, Paek NS, So JS. In Vitro Probiotic Properties of Lactobacillus salivarius MG242 Isolated from Human Vagina. Probiotics Antimicrob Proteins. 2018;10:343. doi:10.1007/s12602-017-9323-5
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- Kumar S, Bansal A, Chakrabarti A, Singhi S. Evaluation of efficacy of probiotics in prevention of candida colonization in a PICU-a randomized controlled trial. Crit Care Med. 2013;41:565. doi:10.1097/CCM.0b013e31826a409c
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